Molecular Biology of Cell

• Part I. Introduction to the Cell
  • Chapter 1. The Evolution of the Cell
    • Introduction
    • From Molecules to the First Cell
    • From Procaryotes to Eucaryotes
    • From Single Cells to Multicellular Organisms
    • References
  • Chapter 2. Small Molecules, Energy, and Biosynthesis
    • Introduction
    • The Chemical Components of a Cell
    • Biological Order and Energy
    • Food and the Derivation of Cellular Energy
    • Biosynthesis and the Creation of Order
    • The Coordination of Catabolism and Biosynthesis
    • References
  • Chapter 3. Macromolecules: Structure, Shape, and Information
    • Introduction
    • Molecular Recognition Processes
    • Nucleic Acids
    • Protein Structure
    • Proteins as Catalysts
    • References
  • Chapter 4. How Cells Are Studied
    • Introduction
    • Looking at the Structure of Cells in the Microscope
    • Isolating Cells and Growing Them in Culture
    • Fractionation of Cells and Analysis of Their Molecules
    • Tracing and Assaying Molecules Inside Cells
    • References
• Part II. Molecular Genetics
  • Chapter 5. Protein Function
    • Introduction
    • Making Machines Out of Proteins
    • The Birth, Assembly, and Death of Proteins
    • References
  • Chapter 6. Basic Genetic Mechanisms
    • Introduction
    • RNA and Protein Synthesis
    • DNA Repair
    • DNA Replication
    • Genetic Recombination
    • Viruses, Plasmids, and Transposable Genetic Elements
    • References
  • Chapter 7. Recombinant DNA Technology
    • Introduction
    • The Fragmentation, Separation, and Sequencing of DNA Molecules
    • Nucleic Acid Hybridization
    • DNA Cloning
    • DNA Engineering
    • References
  • Chapter 8. The Cell Nucleus
    • Introduction
    • Chromosomal DNA and Its Packaging
    • The Global Structure of Chromosomes
    • Chromosome Replication
    • RNA Synthesis and RNA Processing
    • The Organization and Evolution of the Nuclear Genome
    • References
  • Chapter 9. Control of Gene Expression
    • Introduction
    • An Overview of Gene Control
    • DNA-binding Motifs in Gene Regulatory Proteins
    • How Genetic Switches Work
    • Chromatin Structure and the Control of Gene Expression
    • The Molecular Genetic Mechanisms That Create Specialized Cell Types
    • Posttranscriptional Controls
    • References
• Part III. Internal Organization of the Cell
  • Chapter 10. Membrane Structure
    • Introduction
    • The Lipid Bilayer
    • Membrane Proteins
    • References
  • Chapter 11. Membrane Transport of Small Molecules and the Ionic Basis of Membrane Excitability
    • Introduction
    • Principles of Membrane Transport
    • Carrier Proteins and Active Membrane Transport ,
    • Ion Channels and Electrical Properties of Membranes
    • References
  • Chapter 12. Intracellular Compartments and Protein Sorting
    • Introduction
    • The Compartmentalization of Higher Cells
    • The Transport of Molecules into and out of the Nucleus
    • The Transport of Proteins into Mitochondria and Chloroplasts
    • Peroxisomes
    • The Endoplasmic Reticulum
    • References
  • Chapter 13. Vesicular Traffic in the Secretory and Endocytic Pathways
    • Introduction
    • Transport from the ER Through the Golgi Apparatus
    • Transport from the Trans Golgi Network to Lysosomes
    • Transport from the Plasma Membrane via Endosomes: Endocytosis
    • Transport from the Trans Golgi Network to the Cell Surface: Exocytosis
    • The Molecular Mechanisms of Vesicular Transport and the Maintenance of Compartmental Diversity
    • References
  • Chapter 14. Energy Conversion: Mitochondria and Chloroplasts
    • Introduction
    • The Mitochondrion
    • The Respiratory Chain and ATP Synthase
    • Chloroplasts and Photosynthesis
    • The Evolution of Electron-Transport Chains
    • The Genomes of Mitochondria and Chloroplasts
    • References
  • Chapter 15. Cell Signaling
    • Introduction
    • General Principles of Cell Signaling
    • Signaling via G-Protein-linked Cell-Surface Receptors
    • Signaling via Enzyme-linked Cell-Surface Receptors
    • Target-Cell Adaptation
    • The Logic of Intracellular Signaling: Lessons from Computer-based "Neural Networks"
    • References
  • Chapter 16. The Cytoskeleton
    • Introduction
    • The Nature of the Cytoskeleton
    • Intermediate Filaments
    • Microtubules
    • Cilia and Centrioles
    • Actin Filaments
    • Actin-binding Proteins
    • Muscle
    • References
  • Chapter 17. The Cell-Division Cycle
    • Introduction
    • The General Strategy of the Cell Cycle
    • The Early Embryonic Cell Cycle and the Role of MPF
    • Yeasts and the Molecular Genetics of Cell-Cycle Control
    • Cell-Division Controls in Multicellular Animals
    • References
  • Chapter 18. The Mechanics of Cell Division
    • Introduction
    • An Overview of M Phase
    • Mitosis
    • Cytokinesis
    • References
• Part IV. Cells in Their Social Context
  • Chapter 19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
    • Introduction
    • Cell Junctions
    • Cell-Cell Adhesion
    • The Extracellular Matrix of Animals
    • Extracellular Matrix Receptors on Animal Cells: The Integrins
    • The Plant Cell Wall
    • References
  • Chapter 20. Germ Cells and Fertilization
    • Introduction
    • The Benefits of Sex
    • Meiosis
    • Eggs
    • Sperm
    • Fertilization
    • References
  • Chapter 21. Cellular Mechanisms of Development
    • Introduction
    • Morphogenetic Movements and the Shaping of the Body Plan
    • Cell Diversification in the Early Animal Embryo ,
    • Cell Memory, Cell Determination, and the Concept of Positional Values
    • The Nematode Worm: Developmental Control Genes and the Rules of Cell Behavior
    • Drosophila and the Molecular Genetics of Pattern Formation. I. Genesis of the Body Plan
    • Drosophila and the Molecular Genetics of Pattern Formation. II. Homeotic Selector Genes and the Patterning of Body Parts ,
    • Plant Development
    • Neural Development
    • References
  • Chapter 22. Differentiated Cells and the Maintenance of Tissues
    • Introduction
    • Maintenance of the Differentiated State
    • Tissues with Permanent Cells
    • Renewal by Simple Duplication
    • Renewal by Stem Cells: Epidermis ,
    • Renewal by Pluripotent Stem Cells: Blood Cell Formation ,
    • Genesis, Modulation, and Regeneration of Skeletal Muscle
    • Fibroblasts and Their Transformations: The Connective-Tissue Cell Family
    • Appendix
    • References
  • Chapter 23. The Immune System
    • Introduction
    • The Cellular Basis of Immunity
    • The Functional Properties of Antibodies
    • The Fine Structure of Antibodies
    • The Generation of Antibody Diversity
    • T Cell Receptors and Subclasses
    • MHC Molecules and Antigen Presentation to T Cells
    • Cytotoxic T Cells
    • Helper T Cells and T Cell Activation
    • Selection of the T Cell Repertoire
    • References
  • Chapter 24. Cancer
    • Introduction
    • Cancer as a Microevolutionary Process
    • The Molecular Genetics of Cancer 
    
    
    
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