Molecular Biology of Cell

  • Part I. Introduction to the Cell
    • Chapter 1. The Evolution of the Cell
      • Introduction
      • From Molecules to the First Cell
      • From Procaryotes to Eucaryotes
      • From Single Cells to Multicellular Organisms
      • References
    • Chapter 2. Small Molecules, Energy, and Biosynthesis
      • Introduction
      • The Chemical Components of a Cell
      • Biological Order and Energy
      • Food and the Derivation of Cellular Energy
      • Biosynthesis and the Creation of Order
      • The Coordination of Catabolism and Biosynthesis
      • References
    • Chapter 3. Macromolecules: Structure, Shape, and Information
      • Introduction
      • Molecular Recognition Processes
      • Nucleic Acids
      • Protein Structure
      • Proteins as Catalysts
      • References
    • Chapter 4. How Cells Are Studied
      • Introduction
      • Looking at the Structure of Cells in the Microscope
      • Isolating Cells and Growing Them in Culture
      • Fractionation of Cells and Analysis of Their Molecules
      • Tracing and Assaying Molecules Inside Cells
      • References
  • Part II. Molecular Genetics
    • Chapter 5. Protein Function
      • Introduction
      • Making Machines Out of Proteins
      • The Birth, Assembly, and Death of Proteins
      • References
    • Chapter 6. Basic Genetic Mechanisms
      • Introduction
      • RNA and Protein Synthesis
      • DNA Repair
      • DNA Replication
      • Genetic Recombination
      • Viruses, Plasmids, and Transposable Genetic Elements
      • References
    • Chapter 7. Recombinant DNA Technology
      • Introduction
      • The Fragmentation, Separation, and Sequencing of DNA Molecules
      • Nucleic Acid Hybridization
      • DNA Cloning
      • DNA Engineering
      • References
    • Chapter 8. The Cell Nucleus
      • Introduction
      • Chromosomal DNA and Its Packaging
      • The Global Structure of Chromosomes
      • Chromosome Replication
      • RNA Synthesis and RNA Processing
      • The Organization and Evolution of the Nuclear Genome
      • References
    • Chapter 9. Control of Gene Expression
      • Introduction
      • An Overview of Gene Control
      • DNA-binding Motifs in Gene Regulatory Proteins
      • How Genetic Switches Work
      • Chromatin Structure and the Control of Gene Expression
      • The Molecular Genetic Mechanisms That Create Specialized Cell Types
      • Posttranscriptional Controls
      • References
  • Part III. Internal Organization of the Cell
    • Chapter 10. Membrane Structure
      • Introduction
      • The Lipid Bilayer
      • Membrane Proteins
      • References
    • Chapter 11. Membrane Transport of Small Molecules and the Ionic Basis of Membrane Excitability
      • Introduction
      • Principles of Membrane Transport
      • Carrier Proteins and Active Membrane Transport ,
      • Ion Channels and Electrical Properties of Membranes
      • References
    • Chapter 12. Intracellular Compartments and Protein Sorting
      • Introduction
      • The Compartmentalization of Higher Cells
      • The Transport of Molecules into and out of the Nucleus
      • The Transport of Proteins into Mitochondria and Chloroplasts
      • Peroxisomes
      • The Endoplasmic Reticulum
      • References
    • Chapter 13. Vesicular Traffic in the Secretory and Endocytic Pathways
      • Introduction
      • Transport from the ER Through the Golgi Apparatus
      • Transport from the Trans Golgi Network to Lysosomes
      • Transport from the Plasma Membrane via Endosomes: Endocytosis
      • Transport from the Trans Golgi Network to the Cell Surface: Exocytosis
      • The Molecular Mechanisms of Vesicular Transport and the Maintenance of Compartmental Diversity
      • References
    • Chapter 14. Energy Conversion: Mitochondria and Chloroplasts
      • Introduction
      • The Mitochondrion
      • The Respiratory Chain and ATP Synthase
      • Chloroplasts and Photosynthesis
      • The Evolution of Electron-Transport Chains
      • The Genomes of Mitochondria and Chloroplasts
      • References
    • Chapter 15. Cell Signaling
      • Introduction
      • General Principles of Cell Signaling
      • Signaling via G-Protein-linked Cell-Surface Receptors
      • Signaling via Enzyme-linked Cell-Surface Receptors
      • Target-Cell Adaptation
      • The Logic of Intracellular Signaling: Lessons from Computer-based "Neural Networks"
      • References
    • Chapter 16. The Cytoskeleton
      • Introduction
      • The Nature of the Cytoskeleton
      • Intermediate Filaments
      • Microtubules
      • Cilia and Centrioles
      • Actin Filaments
      • Actin-binding Proteins
      • Muscle
      • References
    • Chapter 17. The Cell-Division Cycle
      • Introduction
      • The General Strategy of the Cell Cycle
      • The Early Embryonic Cell Cycle and the Role of MPF
      • Yeasts and the Molecular Genetics of Cell-Cycle Control
      • Cell-Division Controls in Multicellular Animals
      • References
    • Chapter 18. The Mechanics of Cell Division
      • Introduction
      • An Overview of M Phase
      • Mitosis
      • Cytokinesis
      • References
  • Part IV. Cells in Their Social Context
    • Chapter 19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
      • Introduction
      • Cell Junctions
      • Cell-Cell Adhesion
      • The Extracellular Matrix of Animals
      • Extracellular Matrix Receptors on Animal Cells: The Integrins
      • The Plant Cell Wall
      • References
    • Chapter 20. Germ Cells and Fertilization
      • Introduction
      • The Benefits of Sex
      • Meiosis
      • Eggs
      • Sperm
      • Fertilization
      • References
    • Chapter 21. Cellular Mechanisms of Development
      • Introduction
      • Morphogenetic Movements and the Shaping of the Body Plan
      • Cell Diversification in the Early Animal Embryo ,
      • Cell Memory, Cell Determination, and the Concept of Positional Values
      • The Nematode Worm: Developmental Control Genes and the Rules of Cell Behavior
      • Drosophila and the Molecular Genetics of Pattern Formation. I. Genesis of the Body Plan
      • Drosophila and the Molecular Genetics of Pattern Formation. II. Homeotic Selector Genes and the Patterning of Body Parts ,
      • Plant Development
      • Neural Development
      • References
    • Chapter 22. Differentiated Cells and the Maintenance of Tissues
      • Introduction
      • Maintenance of the Differentiated State
      • Tissues with Permanent Cells
      • Renewal by Simple Duplication
      • Renewal by Stem Cells: Epidermis ,
      • Renewal by Pluripotent Stem Cells: Blood Cell Formation ,
      • Genesis, Modulation, and Regeneration of Skeletal Muscle
      • Fibroblasts and Their Transformations: The Connective-Tissue Cell Family
      • Appendix
      • References
    • Chapter 23. The Immune System
      • Introduction
      • The Cellular Basis of Immunity
      • The Functional Properties of Antibodies
      • The Fine Structure of Antibodies
      • The Generation of Antibody Diversity
      • T Cell Receptors and Subclasses
      • MHC Molecules and Antigen Presentation to T Cells
      • Cytotoxic T Cells
      • Helper T Cells and T Cell Activation
      • Selection of the T Cell Repertoire
      • References
    • Chapter 24. Cancer
      • Introduction
      • Cancer as a Microevolutionary Process
      • The Molecular Genetics of Cancer 


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